Eavesdropping on brain cell chatter
Wednesday, April 16, 2014 · Posted by NIH/National Institute of Neurological Disorders and Stroke
Findings suggest that astrocytes in the mossy fiber system may act as a switch that reacts to large amounts of neuronal activity by raising their levels of calcium. These calcium increases occur over multiple seconds, a relatively long time period compared to that seen in neurons. The spatial extent of the astrocyte calcium increases was also relatively large in comparison to the size of the synapse.
A new cell type is implicated in epilepsy caused by traumatic brain injury
Tuesday, March 11, 2014 · Posted by Tufts University
A new study in mice identifies increased levels of a specific neurotransmitter as a contributing factor connecting traumatic brain injury (TBI) to post-traumatic epilepsy. The findings suggest that damage to brain cells called interneurons disrupts neurotransmitter levels and plays a role in the development of epilepsy after a traumatic brain injury.
Scientists Create Most Detailed Picture Ever of Membrane Protein Linked to Learning, Memory, Anxiety, Pain and Brain Disorders
Thursday, March 6, 2014 · Posted by The Scripps Research Institute
Researchers at The Scripps Research Institute (TSRI) and Vanderbilt University have created the most detailed 3-D picture yet of a membrane protein that is linked to learning, memory, anxiety, pain and brain disorders such as schizophrenia, Parkinson’s, Alzheimer’s and autism. The mGlu1 receptor structure now provides a solid platform for much more reliable modeling of closely related receptors, some of which are equally important in drug discovery.
UNC child neurologist finds potential route to better treatments for Fragile X, autism
Wednesday, October 23, 2013 · Posted by University of North Carolina School of Medicine
Malanga’s finding suggests that not all people with Fragile X share the same biological hurdles. The same is likely true, he said, for people with other autism-related disorders, such as Rett syndrome and Angelman syndrome.
Keeping it Local: Protecting the Brain Starts at the Synapse
Tuesday, October 22, 2013 · Posted by University of California, San Francisco
New research by UC San Francisco scientists shows that one of the brain’s fundamental self-protection mechanisms depends on coordinated, finely calibrated teamwork among neurons and non-neural cells knows as glial cells, which until fairly recently were thought to be mere support cells for neurons.
Researchers ferret out function of autism gene
Monday, September 30, 2013 · Posted by Johns Hopkins Medicine
Scientists say mutations in one such autism-linked gene, dubbed NHE9, which is involved in transporting substances in and out of structures within the cell, causes communication problems among brain cells that likely contribute to autism.
Jackson Laboratory researchers provide definitive proof for receptor’s role in synapse development
Monday, December 31, 2012 · Posted by Jackson Laboratory
Jackson Laboratory researchers led by Associate Professor Zhong-wei Zhang, Ph.D., have provided direct evidence that a specific neurotransmitter receptor is vital to the process of pruning synapses in the brains of newborn mammals.
Animal research suggests new treatment target for epilepsy
Tuesday, July 5, 2005 · Posted by Wake Forest Baptist Medical Center
Through studies in animals, the researchers learned more about the possible brain pathways involved in absence, or petit mal, seizures and tested a drug that revealed a potential new target for blocking seizures before they spread.