OHSU analysis in Annals of Internal Medicine finds journals reported adverse events less frequently

Researchers’ reports in peer-reviewed medical journals often were more favorable to the drug or intervention being studied than the reports on the government website — ClinicalTrials.gov — which required data for specific categories, according to the analysis.

If the technique is found to work with human cells, it could open up new resources for stem cell production and hasten their use in a broad range of medical applications.

Up until now, researchers had assumed that successful SCNT required the use of immature, nonfertilized egg cells, or oocytes, that had to be arrested in a very specific state of development. If an egg cell had been fertilized, and began to divide, scientists believed it was unusable. Mitalipov and his colleagues succeeded in using fertilized eggs that had cleaved into two cells.

The problems people with autism have with memory formation, higher-level thinking and social interactions may be partially attributable to the activity of receptors inside brain cells

The findings add a significant new dimension to basic brain cell function. Scientists have long assumed that brain cell receptors are only active on the surface of cells. The new study shows that receptors can be active inside cells, and their effects can be considerably different from the same receptors located on the cell surface.

A team of scientists recently discovered why cerebellar granule cell neurons in patients suffering from ataxia-telangiectasia (A-T) were unable to repair DNA damage and thus died.

The researchers used genetically engineered mice to show that myoctye-enhancer factor 2D (MEF2D), a transcription factor that turns on specific genes involved in cell survival, is activated after binding to a protein known as A-T mutated (ATM). When the ATM gene that codes for the ATM protein is mutated, thus causing A-T, ATM-MEF2D-survival signals in response to DNA damage are ineffective and may contribute to neurodegeneration.

Preterm birth is the leading cause of infant death and it is also a major contributor to both short and long-term illness.

Rates of preterm birth have been increasing over the past two decades and it is a major public health concern. Children born preterm have higher infant mortality rates than full-term babies and surviving infants are at increased risk of health problems ranging from neurodevelopmental disabilities such as cerebral palsy and intellectual delays to other chronic health problems like asthma.